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In many applications of drug discovery and basic research, classical 2D cell cultures are currently replaced by more complex 3D cell culture models. Depending on the microscope type that is used for imaging, challenges of live cell imaging include phototoxicity, insufficient axial resolution, and limited throughput. In a unique cooperation of Olympus and Novartis, new methods were developed based on two-photon microscopy.

Overcome the boundaries of 3D live cell imaging: How to increase throughput using Two-Photon microscopy of 3D cell cultures in drug discovery

  • Improve spatial resolution for 3D cell models using multiphoton microscopy
  • Revolutionize 3D cell culture screening by multiplying throughput 20x 
    at an exceptional resolution
  • Automatically apply compounds to living organoids for long-term studies

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Overcome the boundaries of 3D live cell imaging: 

How to increase throughput using Two-Photon microscopy of 3D cell cultures in drug discovery